The Horn of Life is a healing item in EarthBound. It is rarely dropped by a few enemies, and can be purchased in Saturn Valley for $1780. The Horn of Life can cure a character's status conditions and revive a dead or diamondized party member to full HP, similar to PSI Healing Ω or a Cup of Lifenoodles. Gone after one use.

Horns of Life are also used in Tenda Village as a form of currency there. One horn will get you a bread roll, two horns will get you some plain yogurt, and so on until trading seven horns, which will earn the player a Hall of fame bat. Manly Fish's Brother has a 1/128% chance of dropping one.