Homesickness is a status ailment in EarthBound. Ness, the only playable character in the game who can be affected by the ailment, will become homesick when he has not contacted his mother for a lengthy period of time, either by Telephone call or in person. Homesickness can cause Ness to miss turns while in combat, during which Ness will instead spend these turns reminiscing about home.
It was rumored that using a Chick would cure homesickness, but this has been proven to be false. Ness's mother will call him on his Receiver phone shortly after Ness begins to feel homesick, reminding him that he should contact her. Despite the fact that they speak, the received call does not cure homesickness.
If the Doctor is talked to while Ness is suffering homesickness, he will point it out by saying: "What a sad look in your eyes… you, the boy in a red cap. You must be homesick. That’s nothing you need to be ashamed of. Anybody who is on a long trip will miss home. In this case, the best thing to do is to call home and hear your mom’s voice." However, Ness's sprite does not actually change; the player can only check if Ness is suffering from homesickness by his lack of action in battle, his Status menu, or inadvertently curing the status ailment by calling Ness's Mother before realizing that Ness is feeling homesick.
In Mother 3, the Mischievous Mole is also able to suffer from homesickness, causing it to miss rather than waste its turn. This also happens to The Squeekz after he battles with Lucas and friends; he then apologizes to them and reminisces about his family on the Highway, making him realize that he should go back to them.