- "Just a tiny bite of those mushrooms will cause terrible hallucinations. Powerful hallucinations that tear at your weaknesses and the scars in your heart. But I'll bring you back to your senses now. ♥"
- — Mixolydia
The Hallucination Mushrooms are the reason that Eerie Smiles to appear in Tanetane Island in Mother 3. When Lucas and friends are hit by Master Eddy's very powerful whirlpool, all of their items that are not equipped vanish (later to be picked up by Ocho) and they are reduced to 1 HP and 0 PP each, they eat the Hallucination Mushrooms to heal themselves. However, the mushrooms also distort their vision and cause hallucinations. Boney does not eat the mushrooms and therefore does not see the hallucinations, although his health is refilled. The music changes to "Red-Green-Yellow-Yellow ♪". Mixolydia is seen as a real woman instead of a Magypsy, and Ocho as a butler instead of an octopus. According to Mixolydia, the mushrooms attack people's weaknesses and scars in their hearts. For example, Lucas sees members of Tazmily Village and family members that mock him and say that everyone hates him. They also trick him by pretending to be Flint, Claus, and other family members and can do back attacks on Lucas. Certain objects will also appear differently. For example, Gift Boxes look like Trash Cans and a pile of sludge is seen as a Hot Spring that Boney refuses to enter.