Sanctuary Guardian is an EarthBound battle theme that plays against 6 of the Sanctuary Guardians, Guardian Digger, Guardian General, Manly Fish's Brother and the Soul Consuming Flame. The song is a remix of Battle With a Dangerous Foe from Mother and another remix being MROB-6720M.
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Sanctuary Guardian meme
This song has become an internet meme in the 2020's, as a way to express confusion or bafflement at a sudden turn of events with the caption "what" put at the bottom with a black border and white outline.