The Drugstore is a special shop in EarthBound. It is a small store that can be found in most towns, the first being Onett. It carries a variety of items, ranging from medicine to weapons and armor. The building also has a payphone and an ATM machine. Different drug stores sell different things, depending on the environment and place within the game. For example, the drugstore in Onett will sell significantly less expensive and powerful weapons than a drugstore in Threed since the Onett drugstore appears long before the drugstore in Threed. These are not to be confused with the Fourside Department Store, which is far larger and contains countless more rooms and floors.
- When looked at on the town map in the Japanese version, the drugstore is marked by the words "DRUG." However, in the English version, they changed the symbol to say "STORE" instead, not wanting any extremely obvious references to drugs.